Susceptibility of GT1–7 cells to mouse-passaged field scrapie isolates with a long incubation
نویسندگان
چکیده
منابع مشابه
Susceptibility of GT1–7 cells to mouse-passaged field scrapie isolates with a long incubation
A typical feature of scrapie in sheep and goats is the accumulation of disease-associated prion protein. Scrapie consists of many strains with different biological properties. Nine natural sheep scrapie cases were transmitted to wild-type mice and mouse-passaged isolates were classified into 2 types based on incubation time: short and long. These 2 types displayed a distinct difference in their...
متن کاملSelective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells
In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion protein (PrPSc) accumulation. We here analyzed the susceptibility of GT1-7 cells to scrapie prions by exposure to infected mouse brains at differen...
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15 صفحه اولSusceptibility of Mycoplasma bovis field isolates to antimicrobial agents
The purpose of this study was to determine the antibacterial susceptibility of field isolates of Mycoplasma bovis originating from the upper respiratory tract of cattle of different ages. Bacteriological examination of 90 nasal swabs collected from calves at three months of age identified M. bovis in 31 (34.44%) samples. Seventeen (18.88%) of these animals still housed M. bovis in their nasal c...
متن کاملDelimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.
Scrapie is a transmissible neurodegenerative disease caused by unusual pathogens called prions. The interval between inoculation and illness for experimental mouse scrapie is dramatically influenced by an incubation time gene (Prn-i) that is linked to Prn-p, the structural gene for prion protein (PrP). Although prion proteins from mouse strains with short and long scrapie incubation times diffe...
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ژورنال
عنوان ژورنال: Prion
سال: 2014
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.32232